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KMID : 1134820080370070853
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Journal of the Korean Society of Food Science and Nutrition
2008 Volume.37 No. 7 p.853 ~ p.857
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The Micronucleus Test of the Diglyceride Preparation with Conjugated Linoleic Acid by Using Mice
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Hong Soon-Gi
Chung Shin-Kyo
Hyun Sun-Hee
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Abstract
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To assess the clastogenic effects of the diglyceride preparation containing conjugated linoleic acid (DG＋CLA) in vivo micronucleus test was performed using ICR mice. Each of the groups consisted of three doses of DG＋CLA (500, 1,000 and 2,000 mg/kg, p.o.), Mitomycin C (positive control, 2 mg/kg, i.p.) and negative control (olive oil, 10 mL/kg, p.o.). A slide preparation was made at 24 hours after 1st treatment with DG＋CLA. As a result of counting the micronucleated polychromatic erythrocyte (MNPCE) of 2,000 polychromatic erythrocyte (PCE), the number of aberrant cells was not increased in any of the three doses of DG＋CLA orally administered. There was no clinical sign connected with administration of DG＋CLA. These results indicate that DG＋CLA is not capable of inducing micronuclei in vivo mice cells and thus has no genotoxicity in micronucleus.
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KEYWORD
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diglyceridepreparationcontainingconjugatedlinoleicacid, micronucleus, micronucleatedpolychromaticerythrocyte, polychromaticerythrocyte
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